How a Gene Found in Every Human Cell Could Be Causing Obesity

How a Gene Found in Every Human Cell Could Be Causing Obesity

by Victoria Simpson

Earlier in 2015 researchers identified more than 100 regions on the human genome that they believe to be connected with our perception of hunger and the distribution of fat in the body, and in turn, connected with the causes of obesity.

Recent experiments are confirming this, an article in the Vancouver Sun states. The gene that encodes the 14-3-3zeta protein seems to be the culprit.

When it was switched on, mice involved in a study gained weight. When the gene was turned off, the mice revealed a 50-percent reduction in their unhealthy ‘white fat’, even when they ate the same amount of food as before.

Gareth Lim, a postdoctoral fellow at University of British Columbia’s Life Sciences Institute who conducted the studies says, “People gain fat in two ways – through the multiplication of their fat cells, and through the expansion of individual fat cells.”

He believes that the protein involved in the study affects the number of cells in the body, and how big they are.

how-to-lose-weight-fastLim’s study was conducted with cellular and physiological science professor James Johnson and was published in the journal Nature Communications.

Researches believe that future drug therapy could be developed based on these new findings, and that it could work by suppressing the gene responsible for turning the 14-3-3zeta protein on and off, or by blocking the protein.

Doctors currently recommend that individuals suffering form obesity use dietary changes, exercise and activity, behavior changes and counseling as primary tactics for losing weight. Prescription weight-loss medication and weight-loss surgery can be applied in certain cases, along with these primary tactics.

Prescription weight-loss medication is normally used when other methods of weight loss haven’t worked for an individual, and the individual has a body mass index of 30 or greater, or 27 or greater with complications such as diabetes, high blood pressure or sleep apnea.

Weight loss surgery is only recommended for those who suffer from extreme obesity with a BMI of 35 to 39. 9 combined with serious weight-related health problems. Individuals must be committed to making the lifestyle changes necessary for the benefits of surgery to work.











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